ИСТИНА

1. First system analysis of PSP spectrum in fungal genomes was performed. 2. Analysis of 33 fungal genomes revealed homologs for 10 from 15 examined human peptidases, capable of hydrolyzing the bonds formed by proline residue, and one specific for fungi acid PEP. 3. APP1, APP3, DPP4, CND and PEP were present in the majority of studied species; POP and LAP were found mainly in Basidiomycetes, FAP was specific to Sordariomycetes, prolidase was distributed mosaically, and prolyl carboxypeptidases was found in single species of fungi. 4. Presence or lack of the examined PSP in fungal species is mostly determined by taxonomical position.