ИСТИНА

The creation of highly sensitive, selective sensor systems based on plasmonic nanocomposites with controlled spectral and recognition properties for multiplex determination of biologically active substances and ecotoxicants is an important task of modern biological and environmental monitoring. A nanocomposite is a multicomponent material with new improved properties (sensitivity, selectivity, stability and reproducibility), consisting of a optically transparent polymer base (matrix), nanoparticles of noble metals of various sizes and shapes, additional reagents that help reduce background signals from analytes and/or the matrix of the analyzed samples, prevent oxidation of the surface or analytes, as well as recognizing indicator substances that, when interacting with the analyzed substance or their group (in multiplex determination), provide the appearance of characteristic - sensitive and selective signals in the Raman spectrum. The report will focus on obtaining nanostructured polymeric materials with conductive properties for their use in the electrochemical (EC) version of surface-enhanced Raman spectroscopy (SERS) analysis (EC-SERS), and the creation of photocatalytic materials. Approaches to control the hydrophilicity/hydrophobicity of the sensor surface and its surface charge will also be discussed. This will not only expand the range of analyzed samples, but also regulate the orientation of analyte molecules (specific functional groups) on the plasmonic surface. The latter will increase the selectivity of the SERS method due to the possibility of multiplex determination of molecules similar in structure and properties. The development of such new multifunctional approaches in the creation of plasmonic sensors will significantly expand the analytical capabilities of surface-enhanced Raman spectroscopy, move from high-resolution devices to portable equipment, thereby making the method available for use in clinical diagnostic laboratories, biological and environmental monitoring, in quality control of pharmaceutical and food products at various industry enterprises, etc.