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The environmentally sound management of chemicals and all types of waste is a complex target. To resolve this problem more effectively, the fact, that substances contained in chemicals and wastes could have antagonistic properties, must be taken into account. The combined effect of alkaline salinity and petroleum products on the growth characteristics of the garden cress Lepidium Sativum seedlings was studied. Earlier, the data were obtained that salinity affects the garden cress seedlings sensitivity to oil products [2]. Seeds were germinated in aqueous solutions of sodium carbonate, sodium silicate, and sodium phosphate. To obtain solutions with a pH level of about 11, saturated solutions of the salts mentioned above were diluted 600-700-fold. For garden cress the optimum soil pH value is 6-7. If pH level is about 11, seeds would not germinate. We do not give the exact value of the solution concentrations, since the chemistry of natural compounds and processes is the chemistry of mixtures; therefore, the accurate concentrations in such studies are insignificant. The garden cress seeds cultivation in solutions of sodium carbonate or sodium silicate (pH level is about 11) with the addition of oil products (diesel fuel) at a concentration of 0.3−0.5 g/l makes it possible to obtain the one-week-age garden cress seedlings with roots and shoots of a few millimeters long. Wherein, the lengths of shoots and roots of one-week-age garden cress sprouts grown in distilled water (the control point) are about 30-70 mm. The petroleum products addition to solutions of sodium phosphate does not result in a similar effect. Seeds do not germinate in such solutions. Thus, the environmentally sound management of chemicals and all waste should take into account the possible antagonism of substances.