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Recently different kinds of nanostructures and nanomaterials become more and more interest for applications in high energy density physics experiments. In particular, in experiments with powerful laser pulses special nanometer foil and nanocluster structures are actively used as targets which have shown the eciency for generation in plasma of intensive streams of ions, electrons, gamma and x-ray quanta. At the same time development of special thinfilm detectors of ionizing radiation and multilayered or gradient materials for optical components is a very perspective direction. Methods for surface nanomodifications by influence of coherent radiation with intensity near an ablation threshold intensively expand. Progress in these elds demands development of the corresponding high-precision tools for creation and diagnostics of surface nanostructures. Thus, one of the most powerful methods of a surface research is the scanning probe microscopy. We present our original experimental setup designed around scanning probe unit for manipulations in ultra-high vacuum (1E-����11mbar) (UHV) and very low temperature (down to 280 mK) with presence of magnetic elds (up to 7 Teslas). The main unit of the setup is AFM/STM unit especially designed for using in UHV systems in in-situ experiments where high spatial resolution (up to atomic and subatomic) is required. Scanning unit of our STM is equipped by lateral sample positioning system and tip landing system. Sample positioning system consists of three pairs of inertial piezo-drivers, positioned in the vertexes of a regular triangle and sapphire sample holder in between them. The sample holder is equipped by eight contacts which are used either for xation of a standard "Omicron Nanotechnology" sample holder or as independent electric contacts for dierent goals like a sample heating. Setup possibilities allow to use it in researches and development of new