ИСТИНА

Biological compensatory mechanisms is the dynamic, physiological way of adaptation. They will be mobilized as soon as the organism gets to inadequate conditions, and they can decrease gradually or lead to irreversible processes of the functional reorganization of an alive organism and to appearance of steady mutations. The research of a clinical course of hemophilia showed that some patients have decreased level of coagulation plasma factors, such as antithrombin III, protein C , protein S, hyperfibrinolysis. In combination with other protrombotic factors it can lead to decrease of annual rate of bleedings for patients with hemophilia. It can be considered as the compensatory mechanisms that decrease severity of hemophilia. The research of a large number of patients with hemophilia established that some mutations can exert positive impact on a disease phenotype, and they also represent the compensatory mechanisms developed as a result of evolutionary processes. It was discovered that the annual rate of bleedings in the presence of the Leiden mutation and the prothrombin mutation are 5 times lower, than for patients with hemophilia without these mutations. The Leiden mutation and a prothrombin mutation considered to be inherited mutations, i.e. they appeared at patients with a hemophilia as a result of the complex evolutionary changes, as organism adaptation to the present disease. And these heritable mutations can also be considered as compensatory mechanisms of self-regulating systems.