ИСТИНА

Anticontractile effect of endothelium is eliminated in coronary arteries of adult rats, which suffered from antenatal/early postnatal hypothyroidism. This is associated with reduced basal activity of NO-pathway. Long-lasting coronary endothelial dysfunction resulted from transient thyroid deficiency during the antenatal/early postnatal period can be corrected by voluntary exercise training. Such beneficial effects of exercise training can reduce the risk of delayed coronary artery disease in the progeny exposed to the low thyroid hormones level during intrauterine life.