ИСТИНА

Creating drugs based on using natural compounds as auxiliaries can in some cases effectively address targeted delivery of substances to biological targets because of their structural similarity. It should also be borne in mind that the use of well-known and used in practice anthelmintic substances and the latest achievements in supramolecular chemistry is one of the most efficient, effective and promising areas of modern biotechnology. This significantly reduces implementation time of new drugs in the practice of veterinary medicine and addressed topical issues of import substitution. Our research on the development of medicines for veterinary use by mechano-chemical modification of substances known anthelmintic substances, water-soluble polymers in order to increase their effectiveness and range of action allow you to create and offer to the practical application of innovative anthelmintics, retain high activity while reducing the active ingredient application rate (up to 10 times or more ). This report will be presented data on solid-phase synthesis by joint mechanical treatment of anthelmintic drugs on the basis of benzimidazole derivatives (carbendazim, albendazole, fenbendazole, triclabendazole) and natural substances (polysaccharides, saponins, etc.). It will be presented the data analysis of the physico-chemical properties of the solid dispersions and the possibility of obtaining supramolecular complexes such as "guest-host". Promising to get innovative products is confirmed by the data obtained in laboratory models and experimental animals in tests of their anthelmintic activity.