ИСТИНА

The results reported in the literature suggest that partitioning of chromosomes into so-called topologically associated domains (TADs) is directly related to the partitioning of the genome into active and repressive segments. The fractal globule model was believed to describe TADs structure, but no clear observation of distinct domains was observed yet. We perform computer simulation of a polymer chain folding composed of blocks of inactive units (mimicking non-acetylated reversibly associating units) interspaced by shorter blocks of active chromatin (mimicking acetylated non-associating units). We show that only usage of saturating interactions allows obtaining of contact maps similar to real Hi-C maps.