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Nanodrugs, developed in the V.N.Orekhovich Research Institute of Biomedical Chemistry (Moscow) from soybean phosphatidylcholine, were characterized via small-angle neutron scattering (SANS) at YuMO spectrometer of the IBR-2 reactor (JINR, Dubna) and via X-ray small-angle scattering (SAXS) at DIKSI spectrometer of the synchrotron KISI (NRC "Kurchatov Institute"). Five different nanodrugs (phospholipid transport nanosystem, phospholipovit, indolip, doksolip, nanoarbidol) were characterized via SANS at their concentration in heavy water 5%, 10%, 25% and temperatures 20oС and 37oC. All nanodrugs have vesicular morphology. Vesicle radius, size polydispersity, thickness of the vesicle bilayer and internal structure of the bilayer were calculated from SANS curves taking into account the intervesicle interaction at concentration of nanodrugs 25%. Results show that vesicle morphology are stable under temperature and concentration variation. Important, that main vesicle parameters (radius, polydispersity, and bilayer thickness) for 25% concentration (pharmaceutical concentration) are near to the parameters at 5% concentration (more appropriate concentration for SANS). Comparison of the SANS and SAXS results demonstrates that homogeneous approximation of the scattering length density distribution, which valid in SANS experiment, cannot describe the SAXS experimental curve. More complex approximation could be applied in SAXS experiment for the photon scattering length density distribution across the bilayer. The concept of the critically small vesicle was formulated as vesicle, which internal radius is equal to the bilayer thickness. Our results show that nanodrugs divide on the two families: one based on the phospholipid transport nanosystem and other one based on the phospholipovit. Nanodrugs based on the phospholipid transport nanosystem (phospholipid transport nanosystem and indolip) are small vesicles (radius is three times larger then bilayer thickness). Nanodrugs from phospholipovit family (phospholipovit, doksolip, nanoarbidol) are critically small vesicles. The research was financed by the Russian Scientific Foundation (project № 14-12-00516). References: [1] M.A. Kiselev, E.V. Zemlyanaya, O.M. Ipatova, A.Yu. Gruzinov, E.V. Ermakova, A.V. Zabelin, E.I. Zhabitskaya, O.S. Druzhilovskaya, V.L. Aksenov. J. Pharm. Biomed. Anal. 114 (2015) 288-291. [2] E.V. Zemlyanaya, M.A. Kiselev, E.I. Zhabitskaya, A.Yu. Gruzinov, V.L. Aksenov. Journal of Physics, Conf. series. 724 (2016) 012056, pp. 1-5.