ИСТИНА

: A method for the preparation of dispiroindolinones (I) [X = S or O; R = H, (un)substitute with F, Cl, Br Ph; O H, alkoxy (methoxy, ethoxy, isopropyloxy, propargyloxy), alkyl (Me, Et, Pr, Bu, pentyl, hexyl), R = unsubstituted pyridyl or Ph, substituted by halogen (fluorine, chlorine, bromine), OH, alkoxy (methoxy, ethoxy, isopropyloxy, propargyloxy), aldehyde, alkyl (Me, Et, Pr, Bu, pentyl, hexyl); R = halogen, hydrogen, nitro; R = alkyl (Me, Et, Pr, Bu, pentyl) ; R = H alkyl (Me, Et, propyl)] as anticancer agents is developed. Thus, corresponding imidazolidin-4-one is dissolved in a mono-hydric alc. and boiled at 100±10 °C for 10±2 min. To the boiling mixture are added sarcosine and the corresponding isatin, then the resulting mixture is boiled until the end of the reaction. The prepared compounds were tested as antitumor agents against several cancer cell lines, and showed high level of activity.