Cluster analysis of S. Cerevisiae nucleosome binding sitesстатья
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Дата последнего поиска статьи во внешних источниках: 2 апреля 2018 г.
Аннотация:It is well known that major part of a eukaryotic genome is wrapped around histone proteins
forming nucleosomes. It was also demonstrated that the DNA sequence itself is playing an important
role in the nucleosome positioning process. In this work, a cluster analysis of 67 517 nucleosome
binding sites from the
S. Cerevisiae
genome was carried out. The classification method is based on the
self-adjusting dinucleotides position weight matrix. As a result, 135 significant clusters were
discovered that contain 43225 sequences (which constitutes 64% of the initial set). The meaning of the
found classes is discussed, as well as the possibility of the further usage.