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Selective Inhibition of Enterovirus A Species Members’ Reproduction by Furano[2,3-d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Virusesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 мая 2018 г.
- Авторы: Kozlovskaya Liubov I., Golinets Anastasia D., Eletskaya Anastasia A., Orlov Alexey A., Palyulin Vladimir A., Kochetkov Sergey N., Alexandrova Liudmila A., Osolodkin Dmitry I.
- Журнал: ChemistrySelect
- Том: 3
- Номер: 8
- Год издания: 2018
- Первая страница: 2321
- Последняя страница: 2325
- DOI: 10.1002/slct.201703052
- Аннотация: The rational design of broad-spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N4-hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tick-borne encephalitis virus. Furano[2, 3-d]pyrimidine nucleosides with n-pentyl or n-hexyl tails showed selective inhibition of Enterovirus A representatives. 5-(Tetradec-1-yn-1-yl)-uridine showed selective inhibition of tick-borne encephalitis virus at the micromolar level.
- Добавил в систему: Осолодкин Дмитрий Иванович