Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptorsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
Аннотация:The development of systems for targeted delivery of anti-tuberculosis drugs is a relevant challenge of modern biotechnology. Currently, various carriers are employed to incorporate these drugs such as liposomes, polymers, emulsions and so on. Despite successful in vitro testing of these systems, virtually no success was achieved in vivo, because of low accessibility of the sites of infection located in alveolar macrophage cells. A promising strategy for increasing the efficiency of therapeutic action of anti-tuberculosis drugs is to incorporate the agents into mannosylated carriers with targeting effect to the mannose receptors of alveolar macrophages. The review addresses the methods for modification of drug substance carriers such as liposomes and biodegradable polymers with mannose residues. The use of mannosylated carriers to deliver anti-tuberculosis agents increases the drug circulation time in the blood stream and increases the drug concentration in alveolar macrophage cells.
Bibliography — 113 references.