Respiratory Disease Confirmation via Proteome Analysis of Exhaled Breath Condensate

Fedorchenko, K.Y.; Ryabokon, A.M.; Alexey, K.; Mitrofanov, S.I.; Popov, I.A.; Starodubtseva, N.L.; Anaev, E.C.; Varfolomeev, S.D.; Chuchalin, A.G.; Nikolaev, E.N.

Авторы: Fedorchenko Kristina Y., Ryabokon Anna M., Alexey Kononikhin, Mitrofanov Sergey I., Popov I.A., Starodubtseva Natalia L., Anaev Eldar C., Varfolomeev Sergey D., Chuchalin Alexander G., Nikolaev Eugene N.
Сборник: 14th Human Proteome Organization World Congress - HUPO 2015 Vancouver. Collected volume
Тезисы
Год издания: 2015
Место издания: Ванкувер, Канада
Первая страница: 170
Последняя страница: 171
Аннотация: Nonvolatile biomarker profiling in the cooled breath sample called exhaled breath condensate (EBC) is a completely noninvasive procedure which can be performed even in very severe patients and also repeated within short intervals. Therefore, breath testing is considered to be a potentially ideal candidate for screening purposes. We examined EBC proteomes obtained from 17 patients with chronic obstructive pulmonary disease (COPD), 13 patients with community-acquired pneumonia (CAP) and 23 healthy non-smoking donors. More than 200 different proteins were revealed. It has been demonstrated that the proteomes of each of the groups under consideration differ by specific set of proteins. The results of the proteome analysis were consistent with the clinical picture of the diseases in question. In EBC samples obtained from patients with COPD and CAP cAMP-specific 3',5'-cyclicphosphodiesterases were detected. This result could be a link between analysis of the proteome and lipid composition of exhaled breath condensate in future. In this study, we showed that the proteomic analysis of EBC is informative and has great potential as a method for respiratory disease diagnostics, as it allows not only to identify the differences between the "sick-healthy" groups, but also between different diseases, such as COPD and CAP.
Добавил в систему: Митрофанов Сергей Игоревич

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