Mining for Small Translated ORFsстатьяИсследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 апреля 2018 г.
Аннотация:Peptides encoded by short open reading frames (sORFs) are usually defined as peptides smaller than or equal to 100 aa long. Usually sORFs were ignored by automatic genome annotation programs due to the high probability of false discovery. However, improved computational tools along with a high-throughput RIBO-seq approach identified a myriad of translated sORFs. Their importance becomes evident as we are gaining experimental validation of their diverse cellular functions. This review examines various computational and experimental approaches of sORFs identification, as well as providing the summary of our current knowledge of their functional roles in cells.