Composites Based on Heparin and MIL-101(Fe): The Drug Releasing Depot for Anticoagulant Therapy and Advanced Medical Nanofabricationстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 декабря 2018 г.
Аннотация:We describe the synthesis and properties of the new composite material based on heparin and MIL-101(Fe) metal-organic framework. The intrinsic instability of MIL- 101(Fe) towards hydrolysis enables binding of heparin molecules to the framework structure as is evidenced by DFT calculations and adsorption experiments. The de novo formed heparin-MOF composites showed good biocompat¬ibility in in vitro and demonstrated pronounced anticoagulant activity. The specific interaction between the bioactive molecule and the carrier is critical for the selec¬tive degradation of the complex in the body fluids and for the enhanced activity. Hep_MIL-101(Fe) composite could serve as a drug-releasing depot for nanofabrication and to introduce anticoagulant activity to medical devices and biocoatings. Addition of Hep_MIL-101(Fe) to sol-gel derived thrombolytic matrix allowed to combine anti¬coagulant and thrombolytic activities in a single hybrid nanomaterial that could be applied as a bioactive nanocoating for PTFE vein implants.
DOI 10.1039/C8TB00072G
http://pubs.rsc.org/en/content/articlelanding/2018/tb/c8tb00072g#!divAbstract