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[Radioimmunologic and radioreceptor studies of the pharmacokinetics of the enkephalin analog dalargin in man]статья
Дата последнего поиска статьи во внешних источниках: 23 января 2020 г.
- Авторы: Zaĭtsev S.V., Vinogradov V.A., Sergeeva M.G., Dmitrieva O.F., Ivanikov I.O.
- Журнал: Biulleten' eksperimental'no∎ biologii i meditsiny
- Том: 101
- Номер: 6
- Год издания: 1986
- Издательство: Administrativnoia Zdaniia Minzdrava Sssr
- Местоположение издательства: Moskva, Russia (Federation)
- Первая страница: 702
- Последняя страница: 704
- Аннотация: Pharmacokinetics of dalargin, an opioid hexapeptide, was investigated on 7 males by two approaches. Dalargin radioimmunoassay was performed using a highly specific antiserum reacting only with the whole molecule. In radioreceptor assay lyophilized rat brain membranes containing opiate receptors were used. 2-6 min after intravenous introduction of 1-10 mg dalargin, immunoreactive dalargin blood concentration was lower than 0.5 ng/ml. The results of radioreceptor assay were presented as a biexponential curve with a fast main phase of activity changes (90%, characteristic time 1.5-5.0 min) and a slow "clearance" phase (10% of the substance, characteristic time 85-200 min). Prolonged presence of receptor-active substances in the blood can be attributed to the products of dalargin degeneration, namely its N-terminal penta- and tetrapeptides.
- Добавил в систему: Сергеева Марина Глебовна