Cytogenetic Activity of Gold Gene Nanoparticles in Germ and Somatic Cells of 129 Mice with a Nonsense Mutation in the DNA Polymerase Iotaстатья
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Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
Аннотация:⎯In this study, we investigated the cytogenetic effects of single and quadruple exposure of spermatogenic cells and hepatocytes of 129 mice, which have a mutation in the gene that encodes DNA polymerase iota, to ultrasmall gold nanoparticles (GNPs). The combined effects of GNPs and chemical mutagen dipin were evaluated. In all cases, except for the experiment with the quadruple GNP injection, we observed a slight, statistically nonsignificant increase in the frequency of round spermatids with micronuclei compared to the negative control (saline). It is established that, in the intact liver of 129 mice, in all variants of the experiment, GNPs behaved as a potentially cytotoxic agent, as evidenced by the decrease in the frequency of the
micronucleated hepatocytes.