5-(4-Alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growthстатьяИсследовательская статья
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Дата последнего поиска статьи во внешних источниках: 17 апреля 2018 г.
Аннотация:A series of 5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2'-deoxyuridine have been synthesized by the interaction of 3',5'-diacetyl-5-azidomethyl-2'-deoxyuridine with the corresponding 1-alkynes in a biphasic methylene chloride—water system catalyzed by Cu(I) followed by the deblocking with a water-alcohol ammonia solution. A low cytotoxicity of the compounds in Vero, Jurkat, and A549 cell cultures has been shown. The 2'-deoxyuridine derivatives exhibited an antiherpetic activity in vitro toward two laboratory strains of human herpes simplex virus type 1 (HSV-1): acyclovir-sensitive (HSV-1/L2) and acyclovir-resistant (HSV-1/L2RACV). They also inhibited the growth of some bacteria (Mycobacterium smegmatis, Staphylococcus aureus, Micrococcus luteus, and Leuconostoc mesenteroides) and yeasts Saccharomyces cerevisiae in vitro.