Aspartic and glutamic acids polymers: preparation and applications in medicinal chemistry and pharmaceuticsстатья
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Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
Аннотация:The methods of the fabrication of polymers based on aspartic and glutamic acids asmonomers are reviewed. The methods are perspective from the viewpoint of green chemistryand economics. Actual tendencies existing in the application of the polymers in medicinalchemistry and pharmaceutics are also considered. The results of using mentioned aminoacids polymers to obtain stable nanosized enzymatic complex drugs, based onorganophosphate hydrolase and possessing both antibacterial and antineurotoxic action arepresented. The drugs are effective destructors of N-acyl homoserine lactones, playing therole of signaling molecules for the quorum response of gram-negative bacteria. Theseenzymatic-polymer complexes in combination with well-known antibiotics reduceantimicrobial doses inhibiting growth of the pathogens.