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and Functional Aspects of Helix Association in Membranes: a Computational Viewстатья
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Polyansky A.A., Volynsky P.E., Structural Efremov R.G., Dynamic
- Журнал: Advances in protein chemistry and structural biology
- Том: 83
- Год издания: 2011
- Издательство: Elsevier
- Местоположение издательства: United States
- Первая страница: 129
- Последняя страница: 161
- DOI: 10.1016/B978-0-12-381262-9.00004-5
- Аннотация: This review surveys recent achievements of molecular computer modeling in understanding spatial structure, dynamics, and mechanisms of functioning of transmembrane α-helical dimers in membranes. The factors driving self-association of hydrophobic helices in the membrane milieu are considered with examples of their applications to biologically relevant problems. The emphasis is made on the recent results, which help to understand important aspects of structure-function relations for these systems and their biological activity. Limitations and shortcomings of the methods, along with their perspectives in design of new membrane active agents, are discussed.
- Добавил в систему: Ефремов Роман Гербертович