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Mouse Models Targeting Selenocysteine tRNA Expression for Elucidating the Role of Selenoproteins in Health and Developmentстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
- Авторы: Carlson Bradley, Yoo Min-Hyuk, Tsuji Petra, Gladyshev Vadim, Hatfield Dolph
- Журнал: Molecules
- Том: 14
- Номер: 9
- Год издания: 2009
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 3509
- Последняя страница: 3527
- DOI: 10.3390/molecules14093509
- Аннотация: Selenium (Se) deficiency has been known for many years to be associated with disease, impaired growth and a variety of other metabolic disorders in mammals. Only recently has the major role that Se-containing proteins, designated selenoproteins, play in many aspects of health and development begun to emerge. Se is incorporated into protein by way of the Se-containing amino acid, selenocysteine (Sec). The synthesis of selenoproteins is dependent on Sec tRNA for insertion of Sec, the 21st amino acid in the genetic code, into protein. We have taken advantage of this dependency to modulate the expression of Sec tRNA that in turn modulates the expression of selenoproteins by generating transgenic, conditional knockout, transgenic/standard knockout and transgenic/conditional knockout mouse models, all of which involve the Sec tRNA gene, to elucidate the intracellular roles of this protein class.
- Добавил в систему: Гладышев Вадим Николаевич