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Association of angiotensin-converting enzyme (ACE) gene (insertion/deletion) polymorphism (rs4646994) with migraineстатья
Информация о цитировании статьи получена из
Web of Science
Дата последнего поиска статьи во внешних источниках: 26 января 2018 г.
- Авторы: Sergeev A., Azimova J., Skorobogatykh K., Klimov E., Kondratieva N., Kokaeva Z., Tabeeva G.
- Сборник: Abstracts for IHC2015
- Серия: Cephalalgia: an international journal of headache
- Том: 35
- Год издания: 2015
- Издательство: SAGE Publications
- Местоположение издательства: United States
- Первая страница: 268
- Последняя страница: 268
- DOI: 10.1177/0333102415581304
- Аннотация: Background: The relationship between genetic polymorphisms, migraine and endothelial dysfunction are physiologically convincing but remain controversial. Aim: The present study was aimed to investigate the relationship between ACE polymorphism (rs4646994) and migraine (both with and without aura). Methods: 137 migraine patients aged 18–65 (112 migraines without aura (MoA), 25 migraines with aura (MwA)) and 153 age- and gender-matched healthy controls were included in the study. We investigated associations between ACE insertion/deletion (I/D) polymorphism and clinical features of migraineurs. Results: Genotypic frequencies: ACE DD 28%, ID 46%, II 26% for MoA group, DD 6%, ID 44%, II 50% for MwA group and DD 35%, ID 40%, II 25% in the control group. The significant association was found between ACE I/I polymorphism and migraine aura (p<0.02). Conclusions: Our data suggested that ACE polymorphism (rs4646994) may play a role in migraine with aura susceptibility in Russian population. Data from this study confirmed a possible relationship between ACE activity, migraine aura and endothelial dysfunction. WOS:000354559400529 DOI: 10.13140/RG.2.1.3149.5447
- Добавил в систему: Климов Евгений Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Сборник | IHC_2015_abstrct_book.pdf | 6,2 МБ | 15 февраля 2016 [KlimovEA] |