Аннотация:In the large-scale high energy physics experiments multi-channel readout application specific integrated circuits (ASICs) are widely used. The ASICs for such experiments are complicated systems, which usually include both analog and digital building blocks. The complexity and large number of channels in such ASICs require the proper methodological approach to their design. The paper represents the mixed-signal design flow of the ASICs for high energy physics. This flow was successfully implemented in the development of the readout ASIC prototypes for the muon chambers of the CBM experiment. The approach was approved in UMC CMOS MMRF 180 nm process. The design flow enables to analyze the mixed-signal system operation on the different levels: functional, behavior