Novel metabolically stable and functionally active mimetic of spermidineстатья
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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.
Аннотация:Earlier unknown 1,8-diamino-3-methyl-4-azanonane (gamma-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N (1)-acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of gamma-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.