The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivativesстатья
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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.
Аннотация:A series of new carbocyclic uracil derivatives were synthesized and evaluated as potential antituberculosis agents. Racemic 1-[4'-hydroxy-2'-cyclopenten-1'-yl]-5-tetradecynyluracil completely inhibited the growth of Mycobacterium tuberculosis H37Rv in vitro at a concentration of 10 mu g/ml. Individual (+) and (-) isomers of the above uracil derivative were isolated and showed the same level of activity against two strains of Mycobacterium tuberculosis: laboratory sensitive (H37Rv) and clinical resistant to five top antituberculosis drugs (MS-115). (C) 2012 Elsevier Ltd. All rights reserved.