Integrator is involved in the human telomerase RNA biogenesisстатьяТезисы
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Аннотация:Telomerase is a key participant of the telomere length maintenance
machinery; it extends 3’-ends of linear chromosomes in
eukaryotic cells. This enzyme is a ribonucleoprotein that contains
telomerase reverse transcriptase and telomerase RNA component.
The processing mechanism of human telomerase RNA involves
exosome trimming or degradation of the primary precursor.
Recent data provide evidence that the competition between the
processing and decay of telomerase RNA may regulate the level of
RNA at the physiological level. However, the events that result in
the appearance of the primary transcript need to be clarified. To
investigate the mechanism of human telomerase RNA processing
we developed a reporter system that allowed us to prove the promoter-
dependent manner of regulation of the hTR transcription
termination. We proposed that the termination of transcription of
hTR may involve Integrator, which is a multisubunit complex supposed
to participate in the regulation of transcription of noncoding
RNAs. With a help of series of different techniques, we have
shown that the Integrator complex is indeed a key component in
the regulation of promoter-dependent transcription termination of
hTR and regulation of further fate of the primary hTR transcript.
This work was supported by Russian Foundation for Basic
Research [17-04-00948 A]; Russian Science Foundation [16-14-
10047]; Lomonosov Moscow State University Development Program
[PNR 5.13].