Silicon nanowire sensor with independent channels for cancer biomarker detectionстатья
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Web of Science
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Дата последнего поиска статьи во внешних источниках: 16 января 2019 г.
Аннотация:Nowadays the number of oncological diseases is growing rapidly around all the world and therefore the early prevent diagnostic of specific biomarkers come in to the forefront of research interest. We present a label-free highly sensitive biosensor based on a silicon nanowire field effect transistor (Si NW FET) with two independent channels, allowing simultaneous detection of various analytes. The developed biosensor was successfully applied for a detection of prostate specific antigen (PSA) in a real serum samples with different concentrations. The sensitivity estimated to be ~23 fg/mL and was two orders of magnitude better than for well-established ELISA methods. The construction of novel sensor allows the separate modification of nanowire surfaces with different specific antibodies and independent measurement of the analytes. We tested the sensor towards simultaneous determination of thyroglobulin (Tg) and thyroid stimulating hormone (TSH) which is important for post-thyroidectomy patients with differentiated thyroid cancer. Both analytes were determined with high selectivity and sensitivity.
The work was supported by the Russian Foundation for Basic Research (RFBR grant ofi-m № 16-29-03266).