|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Chromosomal DNA loops may constitute basic units of the eukaryotic genome organization and evolutionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Автор: Razin S.V.
- Журнал: Critical Reviews in Eukaryotic Gene Expression
- Том: 9
- Номер: 3-4
- Год издания: 1999
- Издательство: Begell House
- Местоположение издательства: United States
- Первая страница: 279
- Последняя страница: 283
- DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.120
- Аннотация: In eukaryotic cell nuclei the genome is organized into large loops attached to the nuclear matrix. Rearrangements of the genome frequently occur via an illegitimate recombination between loop anchorage sites resulting in deletion or repositioning of DNA loops. The illegitimate recombination between loop anchorage sites is possibly mediated by topoisomerase II. Treatments stabilizing intermediate covalent complexes of topoisomerase II with DNA seem to increase the possibility of illegitimate recombination between loop anchorage regions. On the basis of these and some other observations we suggest that chromosomal DNA loops constitute basic units of the genome evolution, or, in other words, structural blocks of the eukaryotic genome.
- Добавил в систему: Разин Сергей Владимирович