[Acetylation of histones in vitro causes chromatin decompactization]статья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:It has been discovered that chemical acetylation of chromatin in vitro by acetyladenylate leads to decrease in the mobility of nucleosomal fiber fragments in agarose gel. Acetylation of HI-depleted chromatin does not produce this effect. Based on these results together with other available data, it is possible to conclude that acetylation causes decompactization of the chromatin fiber. A possible molecular mechanism of in vivo fiber decondensation and interaction of different chromatin compactization levels is discussed.