Yeast protein Nhp6A binds to short GC-rich genesстатьяТезисы
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Аннотация:Nhp6A is a small non-histone chromosomal yeast protein thatnonspecifically binds and bends DNA. This protein is present atmany promoters and transcribed regions of genome and isinvolved in regulation of transcription. Recently it was shownthat Nhp6A participates in destabilization of the nucleosomalstructurein vitrothat may explain its preferential localization atgene promoters and other regulatory loci. The protein is alsofound along the entire length of 176 genes, including the openreading frame. Its function in the coding regions remainsunknown. Aiming to discover the mechanism of action ofNhp6A, we have further studied this group of genes. We calcu-lated length distribution and GC-content of the genes includingnearby areas and compared with an average across the yeast gen-ome. We demonstrated that Nhp6A predominantly binds to thecoding regions of short GC-rich genes. The observed interactionis not associated directly with the high content of GC-pairs inthese DNA loci; therefore a specific, possibly regulatory mecha-nism involving Nhp6A for this group could be proposed. Since apart of Nhp6A-associated genes retain some features of theancestral bacterial genome, we suggest that this genomic distribu-tion of Nhp6 is related to the mechanisms of regulation or main-tenance of gene transcription that appeared early in the course ofevolution. This work was supported by the Russian ScienceFoundation (project no. 14-24-00031