Control of optical transparency and infrared laser heating of costal cartilage via injection of iohexol

Alexandrovskaya, Y.M.; Evtushenko, E.G.; Obrezkova, M.M.; Tuchin, V.V.; Sobol, E.N.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 декабря 2018 г.

Авторы: Alexandrovskaya Yulia M., Evtushenko Evgeniy G., Obrezkova Mariya M., Tuchin Valery V., Sobol Emil N.
Журнал: Journal of Biophotonics
Том: 11
Номер: 12
Год издания: 2018
Издательство: Wiley - VCH Verlag GmbH & CO. KGaA
Местоположение издательства: Germany
Первая страница: e201800195
DOI: 10.1002/jbio.201800195
Аннотация: Infrared (IR) laser impact has no analogues for rapid and safe cartilage reshaping. For better penetration of radiation optical clearing agents (OCAs) can be applied. In present work, the effect of low‐osmolality agent iohexol on costal cartilage is studied. Specifically, it is shown that ½ of total increase of optical transparency occurs in 20 minutes of immersion. Maximally, cartilage transparency on 1560 nm can be increased in 1.5 times. Injection of iohexol results in increased tissue hygroscopicity, lower drying rate and higher percentage of bound water. Effective diffusion coefficients of water liberation at 21°C are (5.3 ± 0.4) × 10^−7 and (3.3 ± 0.1) × 10^−7 cm2/s for untreated and iohexol‐modified tissue, respectively. Raman spectroscopy of irradiated iohexol solution reveals its photo and thermo‐stability under clinically used IR laser energies up to 350 W/cm2 for exposure times of several seconds. At energies higher than 500 cm2/s decomposition of iohexol occurs rapidly through formation of molecular iodine and fluorescent residue.
Добавил в систему: Евтушенко Евгений Геннадиевич

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Control of optical transparency and infrared laser heating of costal cartilage via injection of iohexolстатья

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