|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Multifunctional Composites Based on Graphite Oxide, Doxorubicin, and Magnetic Nanoparticles for Targeted Drug Deliveryстатья Исследовательская статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 3 ноября 2018 г.
- Авторы: Eremina E.A., Kaplin A.V., Eliseev A.A., Sidorov A.V., Radzhabzoda Sh S., Grigorieva A.V., Goodilin E.A.
- Журнал: Nanotechnologies in Russia
- Том: 13
- Номер: 3-4
- Год издания: 2018
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 152
- Последняя страница: 160
- DOI: 10.1134/S1995078018020027
- Аннотация: This work is dedicated to the synthesis of a GO@Fe3O4@DOX multifunctional nanocompositecomposed of graphite oxide, superparamagnetic iron oxide nanoparticles, and the drug doxorubicin. Thefinal product combines double magnetic and molecular targeting to tumor tissues. Superparamagnetic Fe3O4 nanoparticles are first chemically deposited onto a surface of graphite oxide (GO) with the acquisition of a double GO@Fe3O4 composite. The material is then bound with the antitumor drug doxorubicin. The morphology, phase composition, and magnetic and optical properties of synthesized samples are characterized by thermal gravimetry, X-ray diffraction, magnetic susceptibility measurements, transmission electron microscopy, and via UV-visible and Raman spectroscopy. The optimal ratio of graphite oxide, iron oxide, and doxorubicin for the creation of a potential precursor of the new drug is established. The presence of doxorubicin and iron oxide in the composite is confirmed, making it possible to use an external magnetic field for targeted drug delivery towards the affected tissues. It is also shown that the composite retains its stability for a month in solutions with physiological рН values.
- Добавил в систему: Григорьева Анастасия Вадимовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|