Аннотация:Chaperones nucleolin, NCL and nucleophosmin, NPM are
multifunctional proteins involved in the regulations of gene
transcription, RNA synthesis, translation and metabolism, ribosome
biogenesis, chromatin remodeling, control of cell proliferation
and apoptosis, molecular transport and other important processes.1
These proteins over-expressed in highly proliferative tumor cells and
localized presumably in the nucleolus. It has also been revealed that
glycolsilated and phosphorylated nucleolin is highly expressed on
tumor cell surface as receptor for different ligands to trigger molecule
internalization, including potential anti-cancer agents–cationic
peptides. The mechanism of binding between receptor nucleolin and
peptide molecules is unclear; its analysis by molecular docking has
been considered.