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Simulation binding between nucleoli and cationic peptides, inducing tumor cell apoptosis, by molecular dockingстатья
- Авторы: Lushnikova AA, Kostarev AV, Onyan AV
- Журнал: Journal of Cancer Prevention & Current Research
- Том: 2018
- Номер: 9
- Первая страница: 10
- Последняя страница: 15406
- DOI: 10.15406/jpcpr.2018.09.00347.
- Аннотация: Chaperones nucleolin, NCL and nucleophosmin, NPM are multifunctional proteins involved in the regulations of gene transcription, RNA synthesis, translation and metabolism, ribosome biogenesis, chromatin remodeling, control of cell proliferation and apoptosis, molecular transport and other important processes.1 These proteins over-expressed in highly proliferative tumor cells and localized presumably in the nucleolus. It has also been revealed that glycolsilated and phosphorylated nucleolin is highly expressed on tumor cell surface as receptor for different ligands to trigger molecule internalization, including potential anti-cancer agents–cationic peptides. The mechanism of binding between receptor nucleolin and peptide molecules is unclear; its analysis by molecular docking has been considered.
- Добавил в систему: Костарев Александр Владиславович