CHEMICAL-REACTIONS IN DOUBLE-STRANDED NUCLEIC-ACIDS .16. SYNTHESIS OF DNA-DUPLEXES WITH REGULARLY REPEATED CROSS-LINKINGSстатья
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Аннотация:Two self-complementary decadeoxyribonucleotides TAATGC* ATTA (where C* is a derivative of 5-methyl cytosine with a carboxy- or aminofunction attached through a spacer to the exocyclic amino group) were synthesized. Carbodiimide induced condensation of the amino and carboxyl groups in the opposite strands to give the crosslinks with a yield up to 20%. Cross-linking of two opposite strands in the duplex formed by the self-complementary aliphatic amino group-containing decanucleotide was performed with the use of glutaric aldehyde with a similar efficiency. The structure of the dimers obtained and position of the crosslinks were confirmed by the Maxam-Gilbert method. Efficiencies of the T4 DNA ligase-induced polycondensations of the double-stranded modified decanucleotides and of the cross-linked products differed significantly.