Synthesis of modified oligonucleotides and their duplexes with covalently-linked strandsстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:A method for the synthesis of DNA duplex with covalently linked strands was elaborated, and the thermal and hydrolytic stability of the duplex was studied. The strands were connected via an amide bond between carboxyl and aliphatic amino groups in the presence of water-soluble carbodiimide. For this purpose, a series of modified 5- to 26-meric oligonucleotides with primary amino or carboxyl group were prepared, and their properties were investigated.