The p66Shc knockout mice are short lived under natural conditionстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Deletion of the p66Shc gene results in lean and healthy mice,
retards aging, and protects from aging-associated diseases, raising
the question of why p66Shc has been selected, and what is its
physiological role. We have investigated survival and reproduction
of p66Shc) ⁄ ) mice in a population living in a large outdoor
enclosure for a year, subjected to food competition and exposed
to winter temperatures. Under these conditions, deletion of
p66Shc was strongly counterselected. Laboratory studies revealed
that p66Shc) ⁄ ) mice have defects in fat accumulation, thermoregulation,
and reproduction, suggesting that p66Shc has been evolutionarily
selected because of its role in energy metabolism. These
findings imply that the health impact of targeting aging genes
might depend on the specific energetic niche and caution should
be exercised against premature conclusions regarding gene functions
that have only been observed in protected laboratory conditions.
Key words: aging genes; environment; fat; fertility; fitness;
survival.