Optically pure trans-1-benzyl-4-aminopiperidin-3-ols. Synthesis and absolute configurationстатья
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Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
Аннотация:Enantiomerically pure trans-(3R,4R)-4-aminopiperidin-3-ols, which are convenient precursors for making natural and synthetic aminohydroxylated piperidine alkaloid analogs, were efficiently synthesized through the reaction of enantiomerically pure (3R,4S)-3,4-epoxypiperidine with amines in the presence of LiClO(4) in CH(3)CN at room temperature. The absolute stereochemistry of the resultant amino alcohols was determined by the stereochemical correlation method and single-crystal X-ray analysis.