Аннотация:DNA synthesis is commonly accepted to occur as a nucleophilic reaction catalyzed by Zn2+, Ca2+ and Mg2+ ions.
The substitution of these ions with nonmagnetic nuclei by ions with magnetic nuclei was shown to produce a huge
isotope effect: magnetic ions suppress DNA synthesis by 3–5 times with respect to nonmagnetic ones. This observation
unambiguously evidences that the DNA synthesis occurs by radical pair mechanism, which is well known in chemistry
and implies pair wise generation of radicals by electron transfer between reaction partners. Magnetic field dependence
of the DNA synthesis convincingly proves radical pair mechanism, which manifests itself even in the polymerase
chain reaction. This mechanism, being on the energy scale by order of magnitude cheaper that the nucleophilic one,
is switched on, when at least two ions enter into the catalytic site. It coexists with nucleophilic mechanism almost on
a par; their competition is controlled by concentration of ions. Radical pair mechanism is induced by both sorts of
ions, magnetic and nonmagnetic; the only difference is that it functions by 3-5 times more efficiently with magnetic
ions. Nuclear magnetic ions 25Mg2+, 43Ca2+, and 67Zn2+, decreasing catalytic activity of polymerase by 2-3 times, even
more strongly, by 30-50 times, increase mortality of cancer cells. These ions may be considered as the cheap, easily
available, safe (no influence on the immune, signaling and other protein systems), powerful, and universal anti-cancer
means for selective killing cancer cells of any types.