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Fine Structure and Stability of Guest-Host Complexes Fluoroquinolons - Cyclodextrine, Perspective Anti-Tuberculosis Formulationтезисы доклада
- Авторы: Deygen I.M., Egorov A., Kudryashova E.
- Сборник: Future of Biomedicine 2015 Conference
- Тезисы
- Год издания: 2015
- Место издания: Vladivostok
- Первая страница: 84
- Последняя страница: 84
- Аннотация: In the present study we have investigated physico - chemical properties of complexes of fluoroquinolones: ofloxacin (OF), levofloxacin (LV) and moxifloxacin (MF) with 2-hydroxypropyl-β-cyclodextrine in the solutions of pH 2, 4, 7 by FTIR and UV-spectroscopy. Complex formation at pH 2 leads to substantial changes in FTIR spectra, namely, the absorption region of the carbonyl and carboxyl groups and bands aromatic structure quinolone. Because of changes in the structure of the band in 1457 cm-1 (C=C valance vibrations) Kdis = 9 * 10-4M is determined. At pH4 complex formation leads to a similar changes, but in contrast to a pH2, changes in the absorption region C-O-C and C-F in 1080 and 1050 cm-1, respectively, were observed indicating that effective system formation. Complex formation at pH 7 leads to similar, but less significant changes in the spectrum compared to acidic conditions. Apparently low efficiency of complex formation is caused by deprotonation of the carboxyl group. When changing pH of from 4 to 7 a number of changes in the spectrum of complex are detected indicating the influence of pH on the spectrum of drug in complex, but not the dissociation of the complex, which is confirmed by comparison with the spectrum of the free drug. By complex formation with HP-β-CD, the prolonged release of levofloxacin was observed in dialysis experiments. The solubility of fluoroquinolons was enhanced by two-five -fold after inclusion complex formation. The research may provide basis for the development of new drug formulations of FQ based on HP- β-CD as a nanocarrier system. This research is supported by RSF grant 15-13- 00063, Development Program of MSU
- Добавил в систему: Кудряшова Елена Вадимовна