Exploiting Coupling of Boronic Acids with Triols for a pH-Dependent “Click-Declick” Chemistryстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 24 октября 2018 г.
Аннотация:Click-like condensation of boronic acids with specifically designed triols (boronate-triol coupling) produces stable diamantane adducts in aqueous medium, which can be controllably cleaved to initial components under acidic conditions or by using boric acid as a chemical trigger. This novel “click-declick” strategy allows to create temporary covalent connections between two or more modular units that was demonstrated by the synthesis of new fluorophore-labeled natural molecules (peptides, steroids), supramolecular assemblies, modified polymers, boronic acid scavengers, solid-supported organocatalysts, biodegradable COF-like materials and dynamic combinatorial libraries.