Tat basic domain: a ‘Swiss army knife’ of HIV-1 Tat?статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 апреля 2019 г.
Аннотация:Tat (transactivator of transcription) regulates transcription from the HIV provirus. Itplays a crucial role in disease progression, supporting efficient replication of the viralgenome. Tat also modulates many functions in the host genome via its interactionwith chromatin and proteins. Many of the functions of Tat are associated with itsbasic domain rich in arginine and lysine residues. It is still unknown why the basicdomain exhibits so many diverse functions. However, the highly charged basicdomain, coupled with the overall structural flexibility of Tat protein itself, makes thebasic domain a key player in binding to or associating with cellular and viralcomponents. In addition, the basic domain undergoes diverse posttranslationalmodifications, which further expand and modulate its functions. Here, we reviewthe current knowledge of Tat basic domain and its versatile role in the interactionbetween the virus and the host cell.