The Role of Transmembrane Glycoproteins, Integrins and Serpentines in Platelet Adhesion and ActivationстатьяИсследовательская статья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 14 февраля 2019 г.
Аннотация:Platelets are unique cells of human body: they lack nucleus, are rather small in size (1–2 μm) and
involved in several physiological functions, including hemostasis, immunity and angiogenesis. Platelets play
a key role in the initiation of thrombosis upon injury of the blood vessels of the arterial bed, in which blood
flows with high shear rates are observed. According to the generally accepted concepts, the reaction of platelets
to endothelial injury at local shear rates of more than 1000 s–1 is the primary binding of the GPIb-IX-V
receptor complex glycoproteins with von Willebrand factor, a large multimeric blood protein which can specifically
bind to collagen fibers. For further performance of their functions, and first of all, for stable attachment
to the injured surface, platelet has to be activated. There are more than ten types of receptors on the
platelet membrane, which trigger several cascades of intracellular signaling that leads to the restructuring of
the cytoskeleton, granule secretion and activation of integrins, which provide the ability of platelets to strong
adhesion and aggregation. This review is focused on the biophysical aspects of the interaction of transmembrane
glycoproteins and integrins with extracellular ligands, as well as modern ideas about the mechanisms of
platelet activation that is necessary to stabilize their primary adhesion and aggregation.