Determination of methylphosphonic acid in human blood plasma by high-performance liquid chromatography–tandem mass spectrometry

Информация о цитировании статьи получена из Web of Science, Scopus
Дата последнего поиска статьи во внешних источниках: 26 декабря 2018 г.

Авторы: Baygildiev T.M., Rodin I.A., Stavrianidi A.N., Braun A.V., Shpigun O.A., Rybalchenko I.V.
Журнал: Journal of Analytical Chemistry
Том: 72
Номер: 13
Год издания: 2017
Первая страница: 1307
Последняя страница: 1311
DOI: 10.1134/S1061934817130020
Аннотация: Using high-performance liquid chromatography combined with tandem mass spectrometric detection, an approach has been developed for the determination of the most stable nerve agent biomarker, methylphosphonic acid, in human blood plasma. The proposed method is based on the derivatization of methylphosphonic acid with p-bromophenacyl bromide. The optimization of conditions for human plasma sample preparation, mass spectrometric detection conditions, and gradient elution program has been performed. The proposed approach has demonstrated satisfactory reproducibility and selectivity of the determination; the limit of detection for methylphosphonic acid in human plasma was 3 ng mL–1.
Добавил в систему: Байгильдиев Тимур Муратович

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