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A molecular dynamic study of charged nanofilm interaction with negative lipid bilayerстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 20 января 2016 г.
- Авторы: Tsukanov A.A., Psakhie S.G.
- Сборник: INTERNATIONAL CONFERENCE ON PHYSICAL MESOMECHANICS OF MULTILEVEL SYSTEMS 2014
- Том: 1623
- Год издания: 2014
- Место издания: AIP Publishing Tomsk, Russia
- Первая страница: 639
- Последняя страница: 642
- DOI: 10.1063/1.4899026
- Аннотация: Hydrophobic and functionalized nanoparticles of different sizes and shapes have a various biomedical application, in particular anticancer therapy. It is known that charged nanoparticles may bind lipids and membrane proteins as well as cause lipid bilayer disruption. We have performed preliminary molecular dynamic simulations to investigate the effect of positively charged synthetic nanofilm, imitating a fragment of the two-dimensional folded AlOOH structure, on the POPE/POPG lipid membrane. It has been shown that the synthetic nanofilm with frozen coordinates tightens the membrane and binds lipid headgroups. Furthermore, the presence of the positively charged nanofilm perturbs the cation concentration in the near-surface membrane region.
- Добавил в систему: Цуканов Алексей Алексеевич