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The influence of some retarding agents NOS of dihydrothiazine-thiazoline rank on postradiational of recovery endogenous CFU-S-8 of miceстатья
Статья опубликована в журнале из списка RSCI Web of Science
Информация о цитировании статьи получена из
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Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Konopliannikov A.G., Proskuriakov S.I., Konopliannikov O.A., Trishkina A.I., Shteǐn L.V., Verkhovskiǐ I.G., Kolesnikova A.I., Trofimova T.P., Mandrugin A.A., Fedoseev V.M., Bachurin S.O., Proshin A.N., Skvortsov V.G.
- Журнал: Радиационная биология. Радиоэкология
- Том: 47
- Номер: 1
- Год издания: 2007
- Издательство: ФГБУ "Издательство "Наука"
- Местоположение издательства: Москва
- Первая страница: 5
- Последняя страница: 9
- Аннотация: In this work the attempt to estimate a nitric oxide (NO*) role in regulation of the number of pool haemopoietic stem cells at the irradiated mice was made. With this purpose the number of new compounds from dihydrothiazine-thiazoline line was synthesized, their NO-inhibiting activity was investigated in vivo by the method of ESR-spectroscopy of spin trap and their influence on an output endogenous spleen colonies (CFU-S-8) after the total sublethal y-irradiation of mice in a doze of 6 Gy was also investigated. Was shown, that the tested compounds reduced the contents of NO* in a liver tissue of mice which have received an injection of nitric oxide synthesis inductor - lipopolysaccharide, and also increased an output CFU-S-8 forming endogenous colonies in the spleen of the irradiated mice. Received data testify to perceptivity of search radioprotective agents among NO* synthesis inhibitors.
- Добавил в систему: Трофимова Татьяна Петровна