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The Production of Nanoparticles Based on Sulfated Polysaccharides and a Study of Their Anticoagulant Activityстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
- Авторы: Il’ina A.V., Levov A.N., Mestechkina N.M., Drozd N.N., Orlov V.N., Makarov V.A., Shcherbukhin V.D., Varlamov V.P., Skryabin K.G.
- Журнал: Nanotechnologies in Russia
- Том: 4
- Номер: 3-4
- Год издания: 2009
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 244
- Последняя страница: 252
- DOI: 10.1134/S1995078009030124
- Аннотация: Experimental conditions of the formation of nanostructures from sulphated polysaccharide derivatives were selected. Nanoparticles based on galactomannan sulfates, alginic acid, a sulfated derivative of N-carboxymethylchitosan, and structures that simultaneously included galactomannan and chitosan sulfates were obtained for the first time. The formation conditions depended on the nature of the polysaccharides. The size and ζ-potential of the obtained nanostructures were determined. Their anticoagulant activity was studied in two tests: aIIa and aXa. It was shown that the activity of sulfated galactomannans and alginic acid in nanostructures increases when compared to the activity of these polysaccharides in solution.
- Добавил в систему: Орлов Виктор Николаевич