Monoclinic form I of clopidogrel hydrogen sulfate from powder diffraction dataстатья
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Аннотация:The asymmetric unit of the title compound, C(16)H(17)ClNO(2)S+center dot HSO(4) -, (I) [systematic name: (+)-(S)-5-[(2-chlorophenyl)(methoxycarbonyl)methyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium hydrogen sulfate], contains two independent cations of clopidogrel and two independent hydrogensulfate anions. The two independent cations are of similar conformation; however, this differs from that observed in orthorhombic form (II) [Bousquet et al. (2003). US Patent No. 6 504 030]. The H-N-C(chiral)-H fragment shows a trans conformation in both independent cations in (I) and a gauche conformation in (II). In (I), classical intermolecular N-H...O and O-H...O hydrogen bonds link two independent cations and two independent anions into an isolated cluster, in which two cations interact with one anion only via N-H...O hydrogen bonds. Weak intermolecular C-H...O hydrogen bonds further consolidate the crystal packing.