Аннотация:The pt~rpose of the nlaldy: The pregnant women are considered
to be the most vulnerable part of the society subjected to stress
conditions. The effects of acute hypoxia happened on the early
stages of gestation are of particular interest for early gestational
disturbances may interfere in the normal development of pregnancy
or result in perinatal pathology including perinatal hypoxicischemic
brain damage. The severity of the resulting brain damage
is dependent on the intensit:y, duration and time of hypoxia. So
the correction methods of antenatal hypoxia consequences are
very important. One of the most perspective correction methods
is the use of regulatory peptides such as, for example, Semax
(ACTH4_r - PGP) known for its antihypoxic and nootropic properties.
Method~: The white rats' females were subjected to acute
hypobaric hypoxia on the 4-5 th day of pregnancy (the progestational
period) or on the 9-10 th day of pregnancy (beginning
of organogenesis). The morphometric characteristics of newborns
were registered from the 1 ~t to the 60 th day of life. Besides,
the spontaneous behavioral activity and the anxiety level were
investigated in 60-day-old rat pups using the classical behavioral tests while 5-HT-, DA- and NE-levels in brain stem and cerebral
cortex were determined using fluorescent methods.
~.m~ry of results-" We observed that antenatal stress led to
newborn low birth weights and could impact on the developing
brain, The changes of bioamines levels depended on time of hypoxia,
The effects of acute hypoxia happened in the progestational
period were leas eapre~sed than effects of stress happened on
the 9-10 th day of pregnancy, Thus 60-days old males but not
females survived perinatal hypoxia in the progestational period
demonstrated the increased 5-HT level in brain stem while the
other bioamines levels were unchanged, Also the anxiei:y level
was enhanced in males while decreased in females, 60-day old
males from rats subjected to acute hypoxia on the 9-10 tu day of
pregnancy showed the increased levels of NE and DA in brain stem
and cerebral cortex, while females of this group demonstrated
the increase of 5-HT level in brain stem and DA level either
in brain stem or cerebral cortex, 1;asides, 60-day-old rats of
both sexes demonstrated hypoactivity and the decrease of rearing
whereas young ferrales were also less anxious, The intranasal
administration of Semax, 0,01 mg/kg to 60-day-old rat pups eliminated
mentioned above hypoxia-induced influences on bioamines
balance and diminished the antenatal hypoxia induced behavioral
disorganization,
Concision: The perinatal hypoxia seems to contribute to the
development of severe neurological disturbances especially expressed
in 60-day-old males and depended on time of the hypoxia,
In some cases hypoxia induced influences can be eliminated by
intranasal administration of Semax.