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Physicochemical Properties of the Inclusion Complex of Moxifloxacin with Hydroxypropyl-β-Cyclodextrin Synthesized by RESSстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 апреля 2019 г.
- Авторы: Sukhoverkov K.V., Le-Deygen I.M., Egorov A.M., Kudryashova E.V.
- Журнал: Russian Journal of Physical Chemistry B
- Том: 12
- Номер: 7
- Год издания: 2018
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1193
- Последняя страница: 1204
- DOI: 10.1134/S1990793118070126
- Аннотация: A new method for the synthesis of guest–host inclusion complex of moxifloxacin (MF) with2-hydroxypropyl-β-cyclodextrin (HPCD) by supercritical fluid technology in the rapid expansion of super-critical solutions (RESS) mode was suggested for developing new drug formulations with improved bioacces-sibility. The MF–HPCD complex was synthesized by this method as particles of 2–4 µm, which is the opti-mum size for creating the oral and inhalation MF drug forms. According to the scanning electron microscopydata, the morphology of MF–HPCD particles (irregular polyhedra) obtained by RESS processing differsfrom that of the starting components and from that of unbound MF and HPCD obtained by lyophilizationfrom aqueous solution. According to X-ray diffraction data, the crystallinity of MF decreased from 95% to20–30% after the formation of the HPCD complex. The IR spectroscopic and equilibrium dialysis datashowed that RESS provides higher efficiency of drug inclusion in the complex with HPCD compared withthat of conventional methods such as lyophilization or mixing of solid components.
- Добавил в систему: Кудряшова Елена Вадимовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 10.1134S1990793118070126.pdf | 1,1 МБ | 3 февраля 2022 [ElenaKudryashova] |